Summary: The Rhino V5 for Windows user interface was not designed for the new Ultra High Definition, High DPI, or High Resolution displays. These are the details needed to make Windows automatic display scaling work correctly to correct the issue.
Additionally, with the release of Windows 10 Creator's Edition, several commands quit displaying their contents including the Layer panel.
C:\Program Files\Rhinoceros 5 (64-bit)\System\
Is the Rhino UI suddenly shrinking after using a file dialog? Please see this page.