Users of Rhino 4 or 5 who have Wacom tablets often have the following observations:
The Wacom tablet must be set to mouse mode, not pen mode. This was also required with earlier versions of Rhino. But, the difference between V4/V5 and earlier versions is that it wraps the cursor around the active viewport. (Earlier versions wrapped the cursor around the entire monitor.) So you notice the effects quicker.
Note: Rhino 5 has a new option (Tools > Options > View> Viewport properties: Wrap cursor at viewport borders) that lets you enable/disable wrapping cursor around the active viewport.