Users of Rhino 4 or 5 who have Wacom tablets often have the following observations:

1. Viewport panning/zooming/rotating stops working at the border of a view, unlike with the mouse.
2. Viewport panning/zooming/rotating across the border of a view sends the view off to infinity.

The Wacom tablet must be set to mouse mode, not pen mode. This was also required with earlier versions of Rhino. But, the difference between V4/V5 and earlier versions is that it wraps the cursor around the active viewport. (Earlier versions wrapped the cursor around the entire monitor.) So you notice the effects quicker.

Note: Rhino 5 has a new option (Tools > Options > View> Viewport properties: Wrap cursor at viewport borders) that lets you enable/disable wrapping cursor around the active viewport.